Transcription factor e2f8 is involved in the polyploidization during mouse and human decidualization e2f8 is overexpressed in lung cancer and is required for the growth of lc cells e2f8 knockdown reduced the expression of uhrf1 (show uhrf1 antibodies . The mammalian cell cycle is controlled by the e2f family of transcription factors typical e2fs bind to dna as heterodimers with the related dimerization partner (dp) proteins, whereas the atypical e2fs, e2f7 and e2f8 contain two dna-binding domains. E2f8, transcription factor e2f8, e2f transcription factor 8 this gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. Thus, e2f transcription factors, such as e2f8, are essential for orchestrating expression of genes required for cell cycle progression and prolife - ration [30.
E2f8 transcription factors disclaimer: this essay has been submitted by a student this is not an example of the work written by our professional essay writers you can view samples of our professional work here. Need recombinant human transcription factor e2f8 (e2f8) , partial for research find and compare commercial and governmental sources for immunological and biological products using the linscott's directory search engine. Gene id: 1869, updated on 11-mar-2018 summary the protein encoded by this gene is a member of the e2f family of transcription factors the e2f family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small dna tumor viruses. E2f6 (e2f transcription factor 6) belongs to a family of eight transcription factors (e2f1-e2f8), called e2f this family is divided into three groups, and e2f6, e2f7 and e2f8 belong to the third group.
We show that e2f transcription factors bind the e2f8 promoter in vivo and that expression of e2f8 is being induced at the g1/s transition purified recombinant e2f8 binds specifically to a consensus e2f-dna-binding site indicating that e2f8, like e2f7, binds dna without the requirement of co-factors such as dp1. E2f transcription factors and their pathways were highly enriched in the overall transcription factor network perturbed by nastrp (figure 1c supplementary figure 1, available online) from the microarray data, mrna levels of e2f1, e2f2, and e2f8 were markedly downregulated by nastrp in all cell lines we tested ( figure 1d . The e2f family of transcription factors plays a pivotal role in the regulation of cellular proliferation on the basis of sequence homology and function, eight distinct members of e2f. Atypical e2f transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells mainly acts as a transcription repressor that binds dna independently of dp proteins and specifically recognizes the e2 recognition site 5'-tttc[cg]cgc-3.
E2f8, e2f transcription factor 8 vertebrate orthologs 10 human ortholog e2f8, e2f transcription factor 8 orthology source: homologene, hgnc. Fusion genes (updated 2017) data from atlas, mitelman, cosmic fusion, fusion cancer, tcga fusion databases with official hugo symbols (see references in chromosomal bands.
E2fs is a common and important family of transcription factors e2f transcription factors have been widely studied in many organizations, it has many regulating function related to cellular proliferation differentiation, dna repair, cell cycle and cell apoptosis e2f8 is recent identification member. Corroborated that the transcription factor e2f is a e2f6, e2f7 and e2f8 as transcription repressors among the latter subclass, e2f4 shares a similar structure with e2f5, and e2f7 with e2f8. Transcription, representing a ﬁrst step in geneexpression, is tightly regulated by transcription factors (tfs), their co- factors, rna polymerases and chromatin-modifying.
Amplification of the e2f1 transcription factor gene in the hel erythroleukemia cell line saito m, helin k, valentine mb, griffith bb, willman cl, harlow e, look at. E2f8 a gene on chromosome 11p151 that encodes a member of the e2f family of dna-binding transcription factors, which play a key role in regulating cell cycle progression and cell proliferaton. Transcription factor e2f8 is involved in the polyploidization during mouse and human decidualization e2f8 is overexpressed in lung cancer and is required for the growth of lc cells e2f8 knockdown reduced the expression of uhrf1. Abstract the e2f family member of transcription factors includes the atypical member e2f8, which has been little studied in cancer we report that e2f8 is strongly upregulated in human hepatocellular carcinoma (hcc), where it was evidenced to contribute to oncogenesis and progression.
E2f is a group of genes that codifies a family of transcription factors (tf) in higher eukaryotes three of them are activators: e2f1, 2 and e2f3a three of them are activators: e2f1, 2 and e2f3a six others act as suppressors: e2f3b, e2f4-8. 1 results and discussionthe e2f family of transcription factors regulates the expression of many genes that are principally associated with cell cycle-related events including proliferation, differentiation and apoptosis (iaquinta and lees, 2007, mcclellan and slack, 2007, van den heuvel and dyson, 2008.